Determination to Advance Research in Myasthenia Gravis
Discover a clinical trial designed for individuals with Myasthenia Gravis.
Determination to Advance Research in Myasthenia Gravis
Discover a clinical trial designed for individuals with Myasthenia Gravis.
Myasthenia Gravis
In generalized Myasthenia Gravis, a chronic autoimmune disorder affecting nerves and muscles, some antibodies—usually protective—interfere with nerve-muscle communication. This can cause symptoms like muscle weakness, fatigue, or difficulties with speaking, chewing, swallowing, or vision.
Researchers are investigating whether an investigational medication is safe and can reduce antibodies involved in this condition.
Myasthenia Gravis
In generalized Myasthenia Gravis, a chronic autoimmune disorder affecting nerves and muscles, some antibodies—usually protective—interfere with nerve-muscle communication. This can cause symptoms like muscle weakness, fatigue, or difficulties with speaking, chewing, swallowing, or vision.
Researchers are investigating whether an investigational medication is safe and can reduce antibodies involved in this condition.
About the ETNA Study
The ETNA Study is a Phase 2 research study for adults with generalized Myasthenia Gravis (gMG). The study is testing the safety and tolerability (how well your body handles) of an injectable investigational medication called povetacicept, which is given once every 4 weeks. “Investigational” means the medication has not been approved by health authorities.
If you qualify, you’ll be randomly assigned to one of three groups. Neither you nor the study doctor will know which group you’re in. Two groups will receive the investigational medication, and one will receive a placebo, which looks like the investigational medication but doesn’t contain any active medicine. In all groups, patients will continue to receive stable standard of care therapy in addition to either the placebo or the investigational medicine.
You May Qualify for the Study If You
Are 18 – 80 years old and have been diagnosed with gMG
Have one of the antibodies linked to gMG
Have MG symptoms that affect your daily activities and muscle strength
Are taking your usual MG medications and have been on a stable dose
Are 18 – 80 years old and have been diagnosed with gMG
Have one of the antibodies linked to gMG
Have MG symptoms that affect your daily activities and muscle strength
Are taking your usual MG medications and have been on a stable dose
What Will Study Participants Do?
If you choose to join the ETNA study, you will start with a screening visit. This visit helps the study team learn if the study is a good match for you. If you qualify to participate in the study, the main part of the study lasts 12 weeks.
During this period you will receive either the investigational medication or placebo. There is also an optional extension period that you may join for up to 96 more weeks, during which you will receive the investigational medication.
During your screening and study visits, you may:
- Have check‑ins with the study doctor
- Get blood tests and vital signs checked
- Fill out questionnaires about how you’re feeling
- Receive the study medication at no cost
What Will Study Participants Do?
If you choose to join the ETNA study, you will start with a screening visit. This visit helps the study team learn if the study is a good match for you. If you qualify to participate in the study, the main part of the study lasts 12 weeks.
During this period you will receive either the investigational medication or placebo. There is also an optional extension period that you may join for up to 96 more weeks, during which you will receive the investigational medication.
During your screening and study visits, you may:
- Have check‑ins with the study doctor
- Get blood tests and vital signs checked
- Fill out questionnaires about how you’re feeling
- Receive the study medication at no cost
Benefits of Joining a Study
There is no guarantee that taking part in a clinical study will improve your condition or benefit you. But joining a study may help you learn more about your health and support researchers who are working to better understand treatments for people living with gMG.
If you join, you will receive the study medication (investigational medication or placebo) and study‑related care at no cost. You do not need insurance to take part. You will still be responsible for any regular medical care you receive outside of the study.
Some study sites may also offer compensation for your time and travel.
There is no guarantee that taking part in a clinical study will improve your condition or benefit you. But joining a study may help you learn more about your health and support researchers who are working to better understand treatments for people living with gMG.
If you join, you will receive the study medication (investigational medication or placebo) and study‑related care at no cost. You do not need insurance to take part. You will still be responsible for any regular medical care you receive outside of the study.
Some study sites may also offer compensation for your time and travel.
Is Participation Right for Me?
Taking part in this study is completely up to you. You can leave the study at any time and for any reason, and you do not have to explain why. If you take part, you may have the chance to explore more options for managing gMG and work with a study team that understands the condition.
Frequently Asked Questions
Who is sponsoring this study?
This study is sponsored by Vertex Pharmaceuticals, the company developing the investigational medication.
Will I receive the investigational medication if I participate in this study?
If you join the study, you will be randomly placed into one of three groups. Two of these groups will receive the investigational study medication. The other group will receive the placebo.
There is also an optional extension period that you may join, during which you will receive the investigational study medication.
Why should I join this study?
People join studies for many reasons. You may want to learn more about your health, explore new options for managing gMG, or help support research that may benefit others in the future. You’ll also work with a study team that understands gMG.